International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 25(19) (2024)
Role of Diffusion Weighted Magnetic Resonance Imaging in Post-Operative Breast Cancer Patients
Sahar Mahmoud Abd elsalam*1, Sara Ahmed Mohamed1, Naglaa Ezzat Abd elmaged1
1Radiology Department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Breast cancer is the chief reason of cancer death in women, the second most common cancer worldwide, and the fifth most common cause of cancer-related deaths. Following surgical management of breast neoplasm and radiotherapy, the incidence of local recurrence ranges from 1 to 2 percent yearly, with most of the recurrence rates was occurred in the 1st five years. The objective of our study was to evaluate role of Diffusion Weighted MR Imaging (DWI) and Apparent Diffusion Coefficient (ADC) in differentiated between tumor recurrences and benign changes in breast Cancer patients after surgery, so early detection and proper treatment of recurrent disease is of foremost importance. Thirty breast cancer patients with suspicious breast lesions after surgical intervention. After giving informed consent, all patients subjected to sono-mammography, Diffusion Weighted MR Imaging (DWI) and Apparent Diffusion Coefficient (ADC), and their findings compared to histopathology results. This study showed that Sensitivity of sono-mammography was 70% and its specificity was 66.67%. Conventional MRI sensitivity was 85% and specificity was 90%. Regarding sensitivity of ADC&DWI, it was 92.23%while its specificity was 94.51%. The cut off ADC value was 0.95-x 10−3 mm2/s. DWI&ADC are noninvasive techniques that can easily inserted into routine clinical breast MRI protocols. Detection of restricted diffusion can accurately discriminate benign from malignant breast lesions with high sensitivity and specificity. These results confirm the importance of the combined use of both sono-mammography and magnetic resonance image (MRI) for proper differentiation between local tumor recurrence and benign breast changes in breast cancer patients following different surgical procedures.
Keywords: DWI, ADC, Breast cancer recurrence.
Full length article – PDF *Corresponding Author, e-mail: sarahmed1230@gmail.com Doi # https://doi.org/10.62877/102-IJCBS-24-25-19-102