International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 25(19) (2024)
Functional Outcomes After Trans-nasal Prolozone for the Management of Classic Trigeminal Neuralgia; A Prospective Cohort Study of a Novel Technique
Amr Mohamed Saeed1, Mohamed Aysar Khattab2*, Nedaa Selim3
1Department of Anesthesiology, Intensive Care and Pain Management, Military Academy, Cairo, Egypt
2Department of Anesthesiology, Intensive Care and Pain Management, Al-Azhar University, Cairo, Egypt
3Department of Rheumatology and Rehabilitation, Al-Galaa Educational Hospital, Cairo, Egypt
Abstract
Multiple treatment modalities are present for the management of trigeminal neuralgia, including pharmacotherapy and micro vascular decompression. Nevertheless, the application is limited by the sub-optimal efficacy, side effects, and the invasive nature of the surgery. This study aimed to provide a more convenient technique for the management of classic trigeminal neuralgia. This prospective cohort study included 25 cases diagnosed with classic trigeminal neuralgia. The Penn Facial Pain Scale Revised (Penn-FPS-R) was conducted to assess pain interference with the quality of life in the included patients, 1-week before injection, 5 minutes, 15 minutes, one week, 4 weeks and 6 months after injection. The patient’s satisfaction and pain intensity were assessed using the 11-point numeric rating scale (NRS) at the pre-defined time points. This study included 25 cases diagnosed with classic trigeminal neuralgia, and refractory to the standard treatment. Trans-nasal Prolozone revealed an immediate and long-term improvement, regarding pain intensity and quality of life (p value < 0.001). We are the first to describe trans-nasal prolozone infiltration of the sphenopalatine ganglion in the treatment of classic trigeminal neuralgia. Trans-nasal prolozone is simple, self-administered, and easily taughtable technique, which produced dramatic and long-term pain relief in trigeminal neuralgia.
Keywords: Regenerative medicine, prolotherapy, trigeminal neuralgia
Full length article – PDF *Corresponding Author, e-mail: mohamedkhattab.g@gmail.com Doi # https://doi.org/10.62877/77-IJCBS-24-25-19-77