International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 29(23) (2026)
Vitamin K2 Correlation with Cathepsin k and P1NP as markers of bone turnover in Osteoporosis of hemodialysis patients
Ghada Khalifa Sayed 1*, Maha Abdelhadi 2, Amr Raafat Bayomy3, Ahmed Mohamed Hussein3
1*Nephrology Department, Theodor Bilharz Research Institute (TBRI), Giza, Egypt
2 Internal Medicine Department, National Research Centre (NRC), Giza, Egypt
3 Internal Medicine and Nephrology Department, Faculty of Medicine Capital (previously Helwan) University, Cairo, Egypt
Abstract
Bone disease is highly prevalent in patients with chronic kidney disease on dialysis (CKD-5D). It can induce serious bone health problems, especially fragility fractures. Bone disease in patients with CKD-5D is the result of bone turnover abnormalities and the decrease of bone mineral density (BMD) Multiple factors are associated with reduced BMD and may affect bone health. Dual-energy X-ray absorptiometry (DXA) was performed to assess bone mineral density (BMD). Bone mass density. The remodeling process is tightly regulated, when the balance between bone resorption and bone formation shifts to net bone loss results in the development of osteoporosis in both men and women. In this study, we evaluate correlations between vitamin K2 with Cathepsin K as marker of bone resorption and P1N1 as marker of bone formation as well as correlation of vit K2, Cathepsin K and P1N1 with BMD measured by DEXA to access osteoporosis. We also assess the frequency and risk factors of osteoporosis and osteopenia in hemodialysis patients. Vit K2 was significantly lower in osteoporosis patients than osteopenia patients so vitamin K2 level in CKD patients on hemodialysis patients is important for bone health and has close relation to degree of osteoporosis.
Keywords: Osteoporosis, CTHK, P1NP, VitK2, DEXA.
Full length article *Corresponding Author, e-mail: ghadakhalifa05@gmail.com, Doi # https://doi.org/10.62877/1-IJCBS-26-29-23-1,
Submitted: 12-01-2026; Accepted: 22-01-2026; Published: 28-02-2026