International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 27(21) (2025)
The Protective Effect of Urtica dioica L. (Stinging Nettle) on Kidney Injuries Induced by Gentamicin
Asilah Abdullah Abaalkhail1, Waheeba Elfaki Ahmed1, Ali yagoub Mohammed Ahmed2, Seham Alqaraawi1, Razan M AlMohaimeed1, Islam Ragab3*
1Department of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, Buraidah, Saudi Arabia.
2Faculty of Medicine, Ribat University, Khartoum, Sudan.
3Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.
Abstract
The excessive and widespread utilization of antibiotics in modern medical practices has sparked significant concerns regarding the diverse array of side effects and complications accompanying their usage. Gentamicin, among these antibiotics, is notably associated with a heightened risk of nephrotoxicity, particularly when administered in elevated doses or over prolonged treatment durations. In response to this escalating challenge, a surge of interest has emerged in exploring the potential of dietary plants as a prophylactic measure against kidney injuries and nephrotoxicity. Urtica dioica, commonly known as stinging nettle, emerges as a compelling botanical contender, distinguished by its rich composition of bioactive compounds such as flavonoids and phenolic acids renowned for their antioxidative and anti-inflammatory properties. The primary aim of the research endeavors to evaluate the impact of Stinging Nettle (Urtica dioica) on kidney injuries induced by Gentamicin, drawing insights from precedent investigations in the field. Empirical studies have underscored the capacity of Urtica extracts to mitigate oxidative stress, inflammation, and tissue damage in animal models subjected to gentamicin treatment, signaling a promising nephroprotective potential. Additionally, supplementation with Urtica has exhibited enhancements in kidney function markers, indicative of its efficacy in counterbalancing the deleterious effects of gentamicin on renal health. In summation, Urtica presents itself as a propitious adjunctive therapeutic avenue for alleviating the nephrotoxic repercussions of gentamicin and ameliorating renal function. The diverse spectrum of bioactive compounds inherent in Urtica not only holds promise for enhancing the safety and efficacy of antibiotic regimens but also for safeguarding renal health against their detrimental impacts.
Keywords: Stinging Nettle; Kidney; Urtica; antibiotic agent; gentamicin
Full length article*Corresponding Author, e-mail: is.mohamed@qu.edu.sa, chem_islam82@yahoo.com, Doi # https://doi.org/10.62877/39-IJCBS-25-27-21-39