International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]

VOLUME 25(19) (2024)

Synthesis of Acetanilide’s Tertiary Amide Derivatives via Secondary Amines Acylation

Wiame Boumzour^a, Mohamed Merouane El Hammoumi^a*, Safaa El Youssfi^b, Oussama Maazouz^a, Aziz Nassri^a, Abdelhadi El Bachiri^a

^aBio-Geosciences and Material Engineering Laboratory « LBGIM » Ecole Normale Superieure,  Hassan II University, Casablanca, Morocco.

^bLanguage, Literature, Imaginary, and Aesthetics Laboratory, Faculté des Lettres et des Sciences Humaines Sais, Sidi Mohamed Ben Abdellah University, Fes, Morocco

Abstract

This study aims to synthesize derivatives of acetanilide that can be used to find out novel therapeutic effects through a series of tertiary amide molecules which were obtained using, as a first step, the reactions between benzenamine (aniline) and other different molecules which are ketone and aldehyde (benzaldehyde, benzophenone, acetophenone, butanone and acetone). These optimized reactions were performed to produce imines, which were subsequently reduced to secondary amines through using NaBH₄ at 0°C for 12 h. In the second stage, the acylation of these amines was carried out using acetic acid as a solvent and anhydride acetic at 80°C for 30 minutes to yield the desired tertiary amide derivatives of acetanilide. These synthesized molecules were attained in good yields and were characterized using Infrared (IR), Nuclear Magnetic Resonance (NMR) 1H, 13C, and High-performance liquid chromatography-mass spectrometry (HPLC-MS) techniques.

Keywords: Derivatives of Acetanilide, aniline, secondary amine, synthesis, tertiary amine

Full length article – PDF  *Corresponding Author, e-mail: moji82003@yahoo.fr                  Doi # https://doi.org/10.62877/45-IJCBS-24-25-19-45