International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 25(19) (2024)
Comprehensive study of molecular mechanism in Cervical Cancer cell death in vitro and in vivo induced by Phytochemicals
Mriganka Mandal1*, Jishu Mandal2
1*Dr. Kanailal Bhattacharyya College affiliated to University of Calcutta, India
2CSIR – Indian Institute of Chemical Biology, India
Abstract
Biologically active compounds are very effective for any cancer treatment. Conventional chemotherapy has many adverse effects on human health. For this reason, researchers and Scientists are engaged for investigating new weapons for cancer treatment. Cervical cancer is the deadliest type of cancer and the second most common cancer in many countries. Treatment of cervical cancer is based on radiotherapy, chemotherapy, or combined mode of chemo and radiotherapy as well as surgery. Cytotoxicity and cell death induced by many phytochemicals have been studied extensively. Naturally occurring phytochemicals and their derivatives have special attention for the treatment of cervical cancer. The mortality rate of the disease is high among females in many countries. All chemotherapeutics more than 50% are obtained from various sources of plants. Some important phytochemicals like terpenoid, triterpenoid aloe Emodin, and curcumin have important medicinal value. In this context, bioactive compounds targeting for treatment of cancer are highly acceptable. They induce cell malignant cell death in different modes. All deaths are controlled by various signaling pathways. Such as apoptotic death, autophagy death, necrotic, and ferroptosis like this. Current advancements in phytochemical research can be able to identify the action of phytochemicals on malignant cells and the mode of cell death. It has been established that the involvement of death factors is directly or indirectly correlated with the discovery of new drugs. The bioactivity as well as the anticancer activity of phytochemicals has been extensively studied by many groups. The main objective of this review article is to accumulate molecular mechanisms of cell death by different phytochemicals in the case of cervical cancer cells in vivo and in vitro. The targeted molecular pathway of bioactive phytochemicals in cervical cancer will explore the new trail for promising and effective treatment of cervical cancer in the future. All data are collected after extensive Google Scholar, PubMed, Sci-Hub, and NIH searches.
Keywords: Apoptosis, Cervical cancer, Ferroptosis, Phytochemicals, Caspase, p53 protein.
Full length article – PDF *Corresponding Author, e-mail: mriganka0008@gmail.com Doi # https://doi.org/10.62877/44-IJCBS-24-25-19-44