International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 25(19) (2024)
The effect of tea tree oil in combination with antibiotics and toothpastes against Staphylococcus epidermidis
Abubaker Elrotob1*, Idris Kabalci 2,3
1Department of Biomedical Engineering, Engineering Faculty, Karabuk University, Karabuk, Türkiye
2Department of Electric-Electronic Engineering, Engineering and Natural Science Faculty, Uşak University, Uşak, Türkiye
3Department of Electric-Electronic Engineering, Engineering Faculty, Şırnak University, Şırnak, Türkiye .
Abstract
The mouth, where the digestive process initiates, is a crucial organ in the body, necessitating a healthy set of teeth for effective food mastication. However, certain bacteria contribute to biofilm and periodontal pocket formation, leading to an increase in oral and Dental issues. This is especially prominent in areas with bacterial plaque, where germs are becoming more resistant to common antimicrobials and treatments. Natural products such as plant essential oils (EOs), renowned for their antibacterial properties, are utilized to control various microbes. This study aims to evaluate the combined impact of tea tree oil with antibiotics (Augmentin, Amoxicillin, Azithromycin, Metronidazole) and toothpaste brands (Sensodyne, Ipana, Denta, Cariax Gingival Kin) against Staphylococcus epidermidis isolated from the oral environment. The experimental approach involved the disc diffusion method, utilizing 6 mm filter paper discs on Muller Hinton agar. Petri dishes were divided into three sections: one for the antibiotic or toothpaste alone, another for tea tree oil alone, and a third for the combination of tea tree oil with the antibiotic or toothpaste. Following incubation at 37˚C for 24 hours, the inhibition zone diameters were measured. The results demonstrated a significant synergy between tea tree oil and antibiotics/toothpastes, as indicated by the increased average diameter of the inhibition zone after combination. Notably, Metronidazole with oil exhibited an inhibition zone slightly equal to the oil alone, suggesting its ineffectiveness against this bacterium and emphasizing the antimicrobial properties of tea tree oil alone confirming that, the oil is not synergistic with Metronidazole.
Keywords: Tea tree oil, Staphylococcus epidermidis, Antibiotics, Toothpastes, Combined effects.
Full length article – PDF *Corresponding Author, e-mail: elrotobbaba@gmail.com Doi # https://doi.org/10.62877/58-IJCBS-24-25-19-58