International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]

VOLUME 25(19) (2024)

Oral Isotretinoin and Hearing Loss

Z.F. Aref ¹, E.M. Hegazy ², A.R. Abdelaziz ³, M.W.M. Mustafa ³, A. Ali³

¹Otorhinolaryngology Department, Qena Faculty of Medicine, South Valley University, Qena, Egypt.

²Dermatology &Andrology Department, Qena Faculty of Medicine, South Valley University, Qena, Egypt.

³Audiovestibular Unit, 1Otorhinolaryngology Department, Qena Faculty of Medicine, South Valley University, Qena, Egypt

Abstract

Isotretinoin is the only available drug that affects all stages of acne pathogenesis and the success of the treatment with oral isotretinoin seems to greatly improve the social functioning of acne patients. Side effects of isotretinoin are well known, but ototoxicity is rarely reported, and its mechanism is not clear. Therefore, this study was designed to address the possible ototoxic effects of oral Isotretinoin on the inner ears of acne patients. Assessment of the selected sample of patients included full history taking as regards hearing loss, tinnitus, vertigo as well as acne vulgaris. General examination, otorhinolaryngological and dermatological examination were performed. Lipid profile, pure-tone audiometry (PTA) as well as auditory brainstem response (ABR) were conducted both prior to and after oral isotretinoin intake. There was significant difference between serum blood lipids, ABR latencies as well as PTA thresholds at 3000Hz before and after treatment with oral isotretinoin and highly significant difference between PTA thresholds at 4000,6000 and 8000Hz before and after treatment. Serum blood lipids seemed to be a good predictor of the adverse effects of oral isotretinoin on human inner ears.

Keywords: Oral Isotretinoin, Hearing Loss

Full length article – PDF   *Corresponding Author, e-mail: mustafa.mwm.aud@gmail.com                    Doi # https://doi.org/10.62877/56-IJCBS-24-25-19-56