International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 25(19) (2024)
The Polymorphism Association of Visfatin Gene in CAD Patients of North Indian Population
Saif Ali1, Roshan Alam1, Mukhtar Ahmad2, Mohammad Kaleem Ahmad3, Hamanshu Chauhan4, Mohammad Mustafa Khan5, Saba Khan1*
1Department of Biochemistry, Integral Institute of Medical Science and Research, Integral University, Lucknow, India
2Department of Medicine, Integral Institute of Medical Science and Research, Integral University, Lucknow, India
3Department of Biochemistry, King George Medical University, Lucknow, India
4Department of Biochemistry, Hind Institute of Medical Sciences Ataria
5Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, India
Abstract
Visfatin is the adipocytokine that plays a major role in inflammatory processes of atherosclerosis and could be associated with developing coronary artery diseases Hence the study aimed to develop a correlation between frequency distribution of rs61330082 gene polymorphism of visfatin with the development of coronary artery disease. The study was performed on 150 North Indian subjects in which 90 patients were chosen as cases based on CAD diagnosis after performing coronary angiography and rest remaining 60 patients were taken as controls. Biochemical investigation such as lipid test, and glycated Haemoglobin (HbA1c) was performed along with visfatin gene polymorphism that was further compared between CAD patients and healthy controls. The study shows that the mean level of various biochemical parameters was significantly higher in CAD patients (p<0.001). Also, there was a significant association of CC genotype (p<0.001) in CAD patients than in healthy control. Our findings indicate a potential connection between the CC genotype of rs61330082 with the CAD population.
Keywords: visfatin, coronary artery disease, rs61330082
Full length article – PDF *Corresponding Author, e-mail: dr.khan.saba@gmail.com., Ksaba@iul.ac.in Doi # https://doi.org/10.62877/59-IJCBS-24-25-19-59