International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]

VOLUME 25(19) (2024)

Role of Triglycerides High Density Lipoprotein-Cholesterol Ratio in Atherosclerosis in Acute Coronary Syndrome Patients

Ali Moammer Abdulaziz, Salem Husein Karebba, Albasheer Miftah Kindi, Faraj Ahmed Hajjaj

Zliten Medical Center, Alasmarya Islamic University/Medical College, Zliten, Libya

Abstract

                Acute Coronary Syndrome (ACS) is a significant contributor to illness and death on a global scale. The primary cause of ACS is atherosclerosis, which defined as the accumulation of plaque in arterial walls. Dyslipidemia, namely increased triglycerides and decreased high-density lipoprotein cholesterol (HDL-C) levels, is a notable risk factor for the initiation and advancement of atherosclerosis. The TG/HDL-C ratio has identified as a powerful indicator of cardiovascular risk. Gaining a clear understanding of the significance of the TG/HDL-C ratio in atherosclerosis among ACS patients could offer significant knowledge regarding risk assessment and focused treatment approaches. To investigate the relationship between the Triglycerides to High-Density Lipoprotein Cholesterol (TG/HDL-C) ratio and the extent of atherosclerosis in patients with ACS. This cross-sectional study conducted at Zliten Medical Center, Libya, between January 2023 and December 2023 and included 165 The ACS patients categorized into three groups: Group I consisted of patients with unstable angina, Group II included patients with NSTEMI, and Group III comprised patients with STEMI. The participants had clinical and laboratory evaluation, including ECG and echocardiography. The TGs/HDL-C ratio measured in all cases. The mean TG/HDL-C ratio was significantly higher in patients with STEMI than those with NSTEMI and those with unstable angina indicating that TG/HDL-C ratio increases with increase the severity of ACS. The TG/HDL-C ratio is associated with the severity of ACS, with higher ratios observed in STEMI patients. The ratio shows promise as a simple and readily available marker for risk stratification in ACS.

Keywords: Acute Coronary Syndrome, ST-Elevation Myocardial Infarction, Non-ST-Elevation Myocardial Infarction, Unstable Angina, Triglycerides/High Density Lipoprotein-Cholesterol Ratio, Atherosclerosis.

Full length article – PDF   *Corresponding Author, e-mail: alimoammeraziz@gmail.com      Doi # https://doi.org/10.62877/83-IJCBS-24-25-19-83