International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]
VOLUME 26(20) (2024)
Effectiveness of Luteolin as an adjunct to Non-Surgical Periodontal therapy in Stage III Periodontitis Patients: A Randomized Controlled Clinical Trial with Biochemical Analysis
Omer H. Khalafalla1, Hala Abuelela1, Olfat G. Shaker2, Dina A. Osman3, Mahetab AbdalWahab1
1Department of Oral Medicine, Periodontology and, Oral Diagnosis, Faculty of Dentistry, Ain Shams University, Egypt
2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt
3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Girls), Al Azhar University, Egypt
Abstract
Exploring natural compounds to modulate inflammatory responses presents a promising treatment approach for periodontal disease. Herbal remedies are increasingly valued for being natural, cost-effective, and typically free from adverse effects compared to pharmacological options. This study aims to evaluate the impact of luteolin capsules on clinical outcomes and Interleukin-1β (IL-1β) biomarker levels in gingival crevicular fluid (GCF). The current study was conducted on thirty patients selected in this study with generalized periodontitis stage III and grade (A). Patients were randomly divided into two groups; with fifteen subjects in each. Group (I): (Test group) This group was treated with full mouth periodontal mechanical debridement at baseline, followed by oral hygiene measures and was prescribed 50mg luteolin capsules once daily for 45 days. Group (2): (Control group) they were treated with full mouth periodontal mechanical debridement at baseline, followed by oral hygiene measures only. Both groups demonstrated significant improvements in clinical parameters, including plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL), over 3- and 6-month follow-ups. Additionally, IL-1β levels decreased significantly in both groups. The findings suggest that luteolin, when used as an adjunct to non-surgical periodontal therapy, yields clinical outcomes comparable to traditional treatment. However, further research is warranted to explore the efficacy of varying luteolin concentrations.
Keywords: Periodontitis; Non-surgical therapy; Luteolin, Interleukin 1-β.
Full length article *Corresponding Author e-mail: omericare@gmail.com: https://doi.org/10.62877/36-IJCBS-24-26-20-36