International Journal of Chemical and Biochemical Sciences (ISSN 2226-9614)[/vc_column_text][/vc_column][/vc_row]

Start New Submission

 

 

 

VOLUME 28(22) (2025)

Role of Monocyte Subtypes, Presepsin and Interleukin-10 in Early Diagnosis and Survival Rate of Neonatal Sepsis

Esraa Abas Abdallah 1, Abdelrahman A. Elsaied 1, Asmaa Nafady 1, Amr Mohamed Alnoby *1, Ahmed El-Abd Ahmed 2, Khalid A. Nasif 3, 4, Reham Farouk Sayed 1

1Clinical Pathology Department, Faculty of Medicine, South Valley University, Egypt

2Pediatrics Department, Faculty of Medicine, South Valley University, Egypt

3Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia

4Department of Biochemistry, Faculty of Medicine, Minia University, Egypt

Abstract

                Neonatal sepsis, a major cause of newborn mortality, lacks early diagnostic tools. Blood culture delays treatment, while C reactive protein lacks specificity. Cluster of differentiation 14 aids immune response; presepsin is a promising marker. To evaluate monocyte subtypes, presepsin and Interleukin-10, as early predictors in neonatal sepsis. Assess diagnostic accuracy and survival rates. A prospective cohort design with 102 neonates displaying sepsis symptoms. Medical histories, clinical exams, and laboratory tests encompassing blood culture, complete blood count, inflammatory indices including Monocyte to-lymphocyte ratio (MLR), P2/MS and Systemic Inflammation Response Index (SIRI), CRP measurement, flow cytometry for CD14 and CD16, presepsin level determination by immune-enzymometric assay, and IL-10 analysis using ELISA were done to all patients. IL-10 (>20): sensitivity 96.6%, specificity 93.2%. Presepsin (>300 pg/ml): sensitivity 96.5%, specificity 91.1%. WBCs and age correlate with infection risk; IL-10 and CRP are associated with hazard. Gestational age and birth weight are not. Albumin, monocyte subtypes insignificantly associate with mortality. Presepsin and I L-10 are robust biomarkers for sepsis severity. CRP’s diagnostic utility is limited. IL-10 and presepsin predict culture outcomes effectively. Age, WBC count predict infection risk; albumin, specific monocyte subtypes suggest trends in mortality.

Keywords: Monocyte Subtypes, Interleukin-10, Neonatal Sepsis, Survival Rate

Full-length article    *Corresponding Author, e-mail: amrnoby1990@gmail.com, Doi # https://doi.org/10.62877/5-IJCBS-25-28-22-5,

 Submitted: 25-08-2024; Accepted: 15-12-2025; Published: 23-12-2025

 

International Scientific Organization- Atom to Universe

©INTERNATIONAL SCIENTIFIC ORGANIZATION